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Clinical trials show oral ketamine, just like ketamine infusions, are effective for managing treatment-resistant depression, anxiety, bipolar, and post traumatic stress disorder, PTSD. Ketamine is an FDA approved medication safely used in hospitals everyday, even in children. A variant of ketamine, esketamine, received FDA approval for treatment-resistant depression and suicidal ideation. In the last 20 years, new research has proven its effectiveness as a powerful antidepressant.
Ketamine is an alternative treatment for anxiety, depression, PTSD, and substance use. Unlike SSRI’s and other more widely used antidepressants, Ketamine acts quickly. It works on a brain pathway called NMDA. This action is associated with a rapid cessation of looping negative thoughts, as well as decreasing the “Heaviness”/Sadness felt with severe depression. Even more importantly, it can bring about a rapid decline in suicidal feelings. Other research has shown that Ketamine actually causes brain cells to grow many new connections. Patients often report a feeling of their mind being “reset” or “rebooted”. A recent study followed patients treated regularly with the same dose of Ketamine for four years. The Ketamine Effect did not fade with time, and no significant side effects were reported.
Ketamine is especially helpful for Treatment Resistant Depression. The majority of our patients that respond positively to Ketamine have suffered for greater than 10 years and did not get better with multiple other medications. Another recent study showed that although minimally helpful for mild depression, Ketamine is remarkably helpful for those with severe symptoms of depression, and even more so in those with a history of past trauma or childhood trauma.
Oral ketamine is simply a different way for ketamine to enter your body. It is far less invasive and easier to self-administer. The major difference is that infusion therapy has a much higher bioavailability as it is injected directly into your bloodstream. This bioavailability is the reason why oral ketamine doses are actually higher. We have worked extensively with our compound pharmacy to create an oral ketamine lozenge that has consistent and dependable bioavailability.
Yes, ketamine has been available by prescription in the U.S. since the 1970s with its primary use to block sensory perception. Esketamine, the S-enantiomer of racemic ketamine, was approved in 2019 for treatment-resistant depression and is approved for use in depressed patients with acute suicidal ideation or behavior. The use of low-dose ketamine for anxiety and depression is considered “off-label” but is completely legal; last year the American Psychiatric Association published a statement saying that the antidepressant effects of ketamine are both rapid and robust.
Our dose-discovery process ensures we quickly and accurately find the right dose for you. We pay attention to your experience with previous ketamine infusions or other psychedelic experiences. We also make sure to take note of any medication interactions (which is very rare) and any medical issues you may have. Our dose ranges from 2.0 to 5.0 mg/kg body weight, and your medical team will help you find the ideal place to start.
The most common side effects while using ketamine are sedation, confusion, nausea, headache, dizziness, discoordination, and insomnia.
We use a mix of different pharmacies depending on location some of our pharmacies include:
Ketamine is not a miracle cure. Ketamine can be an incredibly important part of starting the process of recovery and successfully managing your depression anxiety PTSD or substance use disorder.
The average patient is treated with a 200mg sublingual Ketamine Troche, one every three days for the first six months. There is a sweet spot for each individual’s Optimal Treatment Dose of Ketamine, a dose that is right and provides the best treatment response. At each thirty day visit, our Ketamine providers will review your scores on standardized scales of Anxiety, Depression, PTSD, and Suicidality. These scores in combination with your interview input will help guide us to your Optimal Treatment Dose.